Non Adherent Patient Definition Essay

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8. Roter DL, Hall JA, Merisca R, Nordstrom B, Cretin D, Svarstad B. Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care 1998. Aug;36(8):1138-1161 10.1097/00005650-199808000-00004 [PubMed][Cross Ref]

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12. Grahame-Smith DG, Aronson JK. Oxford Textbook of Clinical Pharmacology and Drug Therapy. 3rd Edition. Oxford University Press, USA. 2002.

13. World Health Organization. 2003. Adherence to long term therapies: evidence for action [online]. Available at Accessed on June 06, 2010.

14. Carter S, Taylor D, Levenson R. 2005. A question of choice- compliance in medicine taking. From compliance to concordance. 3rd ed. London: Medicines Partnership. Available at: Accessed on June 10, 2010.

15. Ley P. Communicating with patients: improving communication, satisfaction and compliance. Cheltenham, Stanley Thornes Pub Ltd. 1997.

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18. Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA 2002. Dec;288(22):2880-2883 10.1001/jama.288.22.2880 [PubMed][Cross Ref]

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20. Sullivan S, Kreling D, Hazlet T. Noncompliance with medication regimens and subsequent hospitalizations: A literature analysis and cost of hospitalization estimate. J Res Pharmaceut Econ 1990;2:19-33

21. Anon. Poor medication adherence increases healthcare costs. PharmacoEconomics and Outcomes News. 2005;480:5

22. Fuso L, Incalzi RA, Pistelli R, Muzzolon R, Valente S, Pagliari G, et al. Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease. Am J Med 1995. Mar;98(3):272-277 10.1016/S0002-9343(99)80374-X [PubMed][Cross Ref]

23. Garcia-Aymerich J, Barreiro E, Farrero E, Marrades RM, Morera J, Antó JM. Patients hospitalized for COPD have a high prevalence of modifiable risk factors for exacerbation (EFRAM study). Eur Respir J 2000. Dec;16(6):1037-1042 10.1034/j.1399-3003.2000.16f03.x [PubMed][Cross Ref]

24. Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005. Jun;43(6):521-530 10.1097/ [PubMed][Cross Ref]

25. National Council on Patient Information and Education. Enhancing prescription medicine adherence: a national action plan. August 2007. Available at: Accessed on June 5, 2010.

26. Haynes RB, McKibbon KA, Kanani R. Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications. Lancet 1996. Aug;348(9024):383-386 10.1016/S0140-6736(96)01073-2 [PubMed][Cross Ref]

27. Haynes RB, Devereaux PJ, Guyatt GH. Physicians’ and patients’ choices in evidence based practice. BMJ 2002. Jun;324(7350):1350 10.1136/bmj.324.7350.1350 [PMC free article][PubMed][Cross Ref]

28. Cox K, Stevenson F, Britten N, Dundar Y. A Systematic Review of Communication between Patients and Health Providers about Medicine-taking and Prescribing. GKT Concordance Unit, Kings College, 2003.

29. Leupkar RV. Patient adherence: A "risk factor" for cardiovascular disease. The Framington Study. JAMA 1971;215:1617-1625 [PubMed]

30. Tarn DM, Heritage J, Paterniti DA, Hays RD, Kravitz RL, Wenger NS. Physician communication when prescribing new medications. Arch Intern Med 2006. Sep;166(17):1855-1862 10.1001/archinte.166.17.1855 [PubMed][Cross Ref]

31. Rodondi N, Peng T, Karter AJ, Bauer DC, Vittinghoff E, Tang S, et al. Therapy modifications in response to poorly controlled hypertension, dyslipidemia, and diabetes mellitus. Ann Intern Med 2006. Apr;144(7):475-484 [PMC free article][PubMed]

32. Sewitch MJ, Dobkin PL, Bernatsky S, Baron M, Starr M, Cohen M, et al. Medication non-adherence in women with fibromyalgia. Rheumatology (Oxford) 2004. May;43(5):648-654 10.1093/rheumatology/keh141 [PubMed][Cross Ref]

33. Sackett DL, Snow JC. The magnitude of compliance and non compliance. IN Haynes NRB, Taylor DW, Sackett DL, eds. Compliance in Health Care. Baltimore: John Hopkins University Press; 1979:11-22.

34. Dunbar J. Issues in assessment. In: Cohen NSJ. ed. New directions in Patient Compliance. New York: Lexington Books, 1979.p.41-57.

35. Haynes RB, Taylor DW, Snow JC, Sackett DL. Annotated and indexed bibliography on compliance with therapeutic and preventive regimens. In: Haynes RB, Taylor DC, Sackett DL, eds. Compliance in health care. Baltimore: Johns Hopkins University Press, 1979.p.337–474.

36. Francis V, Korsch BM, Morris MJ. Gaps in doctor-patient communication. Patients’ response to medical advice. N Engl J Med 1969. Mar;280(10):535-540 10.1056/NEJM196903062801004 [PubMed][Cross Ref]

37. Sherbourne CD, Hays RD, Ordway L, DiMatteo MR, Kravitz RL. Antecedents of adherence to medical recommendations: results from the Medical Outcomes Study. J Behav Med 1992. Oct;15(5):447-468 10.1007/BF00844941 [PubMed][Cross Ref]

38. Würtemberger G, Hütter BO. Health-related quality of life, psychological adjustment and compliance to treatment in patients on domiciliary liquid oxygen. Monaldi Arch Chest Dis 2000. Jun;55(3):216-224 [PubMed]

39. Oermann CM, Swank PR, Sockrider MM. Validation of an instrument measuring patient satisfaction with chest physiotherapy techniques in cystic fibrosis. Chest 2000. Jul;118(1):92-97 10.1378/chest.118.1.92 [PubMed][Cross Ref]

40. Weingarten SR, Stone E, Green A, Pelter M, Nessim S, Huang H, et al. A study of patient satisfaction and adherence to preventive care practice guidelines. Am J Med 1995. Dec;99(6):590-596 10.1016/S0002-9343(99)80243-5 [PubMed][Cross Ref]

41. Svarstad B. Physician-patient communication and patient conformity with medical advice. In: Mechanic D, ed. The Growth of Bureaucratic Medicine. New York: John Wiley & Sons Inc; 1976.

42. Ley PN, Spellman MS. Communication with the Patient. London: Staples Press; 1967.

43. Meichenbaum D, Turk DC. Facilitating Treatment Adherence: A Practitioner’s Guidebook. New York: Plenum Publishing Corp; 1987.

44. Burnier M. Long-term compliance with antihypertensive therapy: another facet of chronotherapeutics in hypertension. Blood Press Monit 2000;5(Suppl 1):S31-S34 10.1097/00126097-200005001-00006 [PubMed][Cross Ref]

45. Paes AH, Bakker A, Soe-Agnie CJ. Impact of dosage frequency on patient compliance. Diabetes Care 1997. Oct;20(10):1512-1517 10.2337/diacare.20.10.1512 [PubMed][Cross Ref]

46. Praska JL, Kripalani S, Seright AL, Jacobson TA. Identifying and assisting low-literacy patients with medication use: a survey of community pharmacies. Ann Pharmacother 2005. Sep;39(9):1441-1445 10.1345/aph.1G094 [PubMed][Cross Ref]

47. Ward A, Morgan W. Adherence patterns of health in men and women enrolled in an adult exercise program. J Cardiac Rehabil. 1984;4:143-152

48. Ley P. Doctor-patient communication: some quantitative estimates of the role of cognitive factors in non-compliance. J Hypertens Suppl 1985. Apr;3(1):S51-S55 [PubMed]

49. Adisa R, Alutundu MB, Fakeye TO. Factors contributing to nonadherence to oral hypoglycemic medications among ambulatory type 2 diabetes patients in Southwestern Nigeria. Pharmacy Practice 2009;7:163-169. internet. [PMC free article][PubMed]

50. Golin CE, DiMatteo MR, Gelberg L. The role of patient participation in the doctor visit. Implications for adherence to diabetes care. Diabetes Care 1996. Oct;19(10):1153-1164 10.2337/diacare.19.10.1153 [PubMed][Cross Ref]

51. Wagner JH, Justice AC, Chesney M, Sinclair G, Weissman S, Rodriguez-Barradas M, VACS 3 Project Team Patient- and provider-reported adherence: toward a clinically useful approach to measuring antiretroviral adherence. J Clin Epidemiol 2001. Dec;54(Suppl 1):S91-S98 10.1016/S0895-4356(01)00450-4 [PubMed][Cross Ref]

52. Alcoba M, Cuevas MJ, Perez-Simon MR, Mostaza JL, Ortega L, Ortiz de Urbina J, et al. HAART Adherence Working Group for the Province of Leon, Spain Assessment of adherence to triple antiretroviral treatment including indinavir: role of the determination of plasma levels of indinavir. J Acquir Immune Defic Syndr 2003. Jun;33(2):253-258 10.1097/00126334-200306010-00022 [PubMed][Cross Ref]

53. Walsh JC, Mandalia S, Gazzard BG. Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome. AIDS 2002. Jan;16(2):269-277 10.1097/00002030-200201250-00017 [PubMed][Cross Ref]

54. Haynes RB, Taylor DW, Sackett DL, Gibson ES, Bernholz CD, Mukherjee J. Can simple clinical measurements detect patient noncompliance? Hypertension 1980. Nov-Dec;2(6):757-764 [PubMed]

55. Rudd P, Byyny RL, Zachary V, LoVerde ME, Mitchell WD, Titus C, et al. Pill count measures of compliance in a drug trial: variability and suitability. Am J Hypertens 1988. Jul;1(3 Pt 1):309-312 [PubMed]

56. Pullar T, Kumar S, Tindall H, Feely M. Time to stop counting the tablets? Clin Pharmacol Ther 1989. Aug;46(2):163-168 10.1038/clpt.1989.121 [PubMed][Cross Ref]

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58. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol 1997. Jan;50(1):105-116 10.1016/S0895-4356(96)00268-5 [PubMed][Cross Ref]

59. Lau HS, de Boer A, Beuning KS, Porsius A. Validation of pharmacy records in drug exposure assessment. J Clin Epidemiol 1997. May;50(5):619-625 10.1016/S0895-4356(97)00040-1 [PubMed][Cross Ref]

60. Christensen DB, Williams B, Goldberg HI, Martin DP, Engelberg R, LoGerfo JP. Assessing compliance to antihypertensive medications using computer-based pharmacy records. Med Care 1997. Nov;35(11):1164-1170 10.1097/00005650-199711000-00008 [PubMed][Cross Ref]

1. Kleinsinger F. Understanding noncompliant behavior: definitions and causes. Perm J. 2003 Fall;7(4):18–21.

2. Bourbeau J, Bartlett SJ. Patient adherence in COPD. Thorax. 2008 Sep;63(9):831–8.[PMC free article][PubMed]

3. Leichter SB. Making outpatient care of diabetes more efficient: analyzing noncompliance. Clinical Diabetes. 2005 Oct;23(4):187–90.

4. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005 Aug 4;353(5):487–97.[PubMed]

5. Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract. 2008 Jan;62(1):76–87.[PMC free article][PubMed]

6. Ho PM, Spertus JA, Masoudi FA, et al. Impact of medication therapy discontinuation on mortality after myocardial infarction. Arch Intern Med. 2006 Sep 25;166(17):1842–7.[PubMed]

7. O'Connor PJ. Improving medication adherence: challenges for physicians, payers, and policy makers [editorial] Arch Intern Med. 2006;166(17):1802–4.[PubMed]

8. Roter DL, Hall JA, Merisca R, Nordstrom B, Cretin D, Svarstad B. Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care. 1998 Aug;36(8):1138–61.[PubMed]

9. McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA. 2002 Dec 11;288(22):2868–79. Erratum in: JAMA 2003 Jun 25; 289 (24): 3242. [PubMed]

10. Haynes RB, Ackloo E, Sahota N, McDonald HP, Xao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD000011.[PubMed]

11. Emanuel EJ, Emanuel LL. Four models of the physician-patient relationship. JAMA. 1992 Apr 22-29;267(16):2221–6.[PubMed]

12. Bodenheimer T. A 63-year-old man with multiple cardiovascular risk factors and poor adherence to treatment plans. JAMA. 2007 Nov 7;298(17):2048–55.[PubMed]

13. Thom DH, Ribisl KM, Stewart AL, Luke DA. Further validation and reliability testing of the Trust in Physician Scale. The Stanford Trust Study Physicians. Med Care. 1999 May;37(5):510–7.[PubMed]

14. Clabby J, O'Connor R. Teaching learners to use mirroring: rapport lessons from neurolinguistic programming. Fam Med. 2004 Sep;36(8):541–3.[PubMed]

15. Sobel DS. Rethinking medicine: improving health outcomes with cost-effective psychosocial interventions. Psychosom Med. 1995 May-Jun;57(3):234–44.[PubMed]

16. Marks R, Allegrante JP, Lorig K. A review and synthesis of research evidence for self-efficacy-enhancing interventions for reducing chronic disability: implications for health education practice (part I) Health Promot Pract. 2005 Jan;6(1):37–43.[PubMed]

17. Marks R, Allegrante JP, Lorig K. A review and synthesis of research evidence for self-efficacy-enhancing interventions for reducing chronic disability: implications for health education practice (part II) Health Promot Pract. 2005 Apr;6(2):148–56.[PubMed]

18. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000 Jul 24;160(14):2101–7.[PubMed]

19. Stilley CS, Sereika S, Muldoon MF, Ryan CM, Dunbar-Jacob J. Psychological and cognitive function: predictors of adherence with cholesterol lowering treatment. Ann Behav Med. 2004 Apr;27(2):117–24.[PubMed]

20. Stoehr GP, Lu SY, Lavery L, et al. Factors associated with adherence to medication regimens in older primary care patients: the Steel Valley Seniors Survey. Am J Geriatr Pharmacother. 2008 Dec;6(5):255–63.[PMC free article][PubMed]

21. Arlt S, Lindner R, Rösler A, von Renteln-Kruse W. Adherence to medication in patients with dementia: predictors and strategies for improvement. Drugs Aging. 2008;25(12):1033–47.[PubMed]

22. Bryson CL, Au DH, Sun H, Williams EC, Kivlahan DR, Bradley KA. Alcohol screening scores and medication nonadherence. Ann Intern Med. 2008 Dec 2;149(11):795–804.[PubMed]

23. Golin C. Drinking and drugs: when is enough too much?. [editorial] Ann Intern Med. 2008 Dec 2;149(11):830–2.[PubMed]

24. Soumerai SB, Pierre-Jacques M, Zhang F, et al. Cost-related medication nonadherence among elderly and disabled medicare beneficiaries: a national survey 1 year before the medicare drug benefit. Arch Intern Med. 2006 Sep 25;166(17):1829–35.[PubMed]

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